Dervan Group - Research into the bio-organic chemistry of nucleic acids. Including molecular recognition of DNA by small molecules and the design of artificial transcriptional activators. Davis Group - Glycoprocessing enzyme inhibition and mechanism. Exploring enzyme systems. Novel drug delivery systems. Synthesis and use of glycoproteins. Glycoside and oligosaccharide synthesis. Dolbier Jr. Group - Study of the reactivity of free radicals and other reactive fluoroorganic compounds. Danheiser Group - Development of new synthetic methods and strategies, and their application in the total synthesis of natural products and biologically important compounds. Diederich Group - Supramolecular and dendrimer chemistry. Modern medicinal chemistry. Advanced materials based on carbon-rich acetylenic molecular architecture. Synthetic fullerene chemistry. Dudley Group - Devise, develop, and apply new ideas in organic chemistry to the efficient synthesis of interesting molecules, particularly natural products with medicinal applications. Donohoe Group - Asymmetric synthesis and the application of stereoselectve oxidation and reduction reactions to total synthesis.