Nottingham Center for Evidence Based Pathology - Part of a network of evidence-based centres dedicated to research-based, evaluative, clinical practice. Explains the principles of this methodology and its applications. Original research in pathology: judgment, or evidence-based medicine? - Examines whether the practice of anatomic pathology fulfills the tenets of evidence-based medicine (EBM), arguing that anatomic pathology has in fact a unique place in the practice of EBM. Evidence-Based Principles in Pathology: Existing Problem Areas and the Development of “Quality” Practice Patterns - Asks the question "Are pathologists, in fact, as evidence based as they believe?", showing large areas of both anatomic and clinical pathology where evidence-based methodologies have not been applied, and offering constructive suggestions for more systematic application. Evidence-based pathology and the pathologic evaluation of thymomas - Documents the lack of randomized clinical trials evaluating the prognosis of patients with thymomas and the effects of various treatment modalities, and calls for an international cooperative study and meta-analysis of thymomas. [2008] Evidence-Based Pathology and the Pathologic Evaluation of Thymomas - A systematic review and meta-analysis of the prognostic importance of transcapsular invasion in thymoma stage I and II, finding it not a significant prognostic feature of any clinical value. [2008] American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer - ASCO Guideline on how to improve the accuracy of ER and PR testing in breast cancer and on the utility of these receptors as predictive markers. [2010] Evidence-Based Pathology: Systematic Literature Reviews as the Basis for Guidelines and Best Practices - Review of the history and basic concepts of evidence-based medicine and evidence-based pathology, and how to perform and interpret systematic reviews, and integrate best evidence into guidelines. [2015] Evidence Levels for Publications in Pathology and Laboratory Medicine - Discussion of the inadequacies of current schemes for the evaluation of evidence levels, along with a proposed scale of evidence levels for more appropriate to publications in pathology. [2011] Evidence-Based Pathology: Systematic Literature Reviews as the Basis for Guidelines and Best Practices - Reviews history and basic concepts of evidence-based medicine and evidence-based pathology, how to perform and interpret systematic reviews, and how to integrate best evidence into guidelines. [2015] Application of GRADE: Making Evidence-Based Recommendations about diagnostic tests in clinical practice guidelines - Analysis of requirements for clinical practice guidelines in order to facilitate implementation and strengthen confidence in recommendations about diagnostic tests. [2011]